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I'm taking prescription Depakote ER but am having much trouble sleeping for the first time since I started taking the drug two weeks ago. Subscribe To Well as you can see I to can't sleep on the Depakote either. Sleeping aids like Ambien, Lunesta, Prosom, Sominex, and Restoril are not particularly dangerous on their own. Now is the time depakote and sleeping pills, Find Latest Medication For This pill Now! This medicine is sometimes used together with other seizure medications. WARNING: This medication has rarely caused serious (sometimes fatal) liver problems. I was told that it was very sedating and would not need a sleep aid. Depakote & sleep? Tell your doctor if you have a history of depression or mental illness sedatives, tranquilizers, or sleeping pills such as diazepam (Valium) tricyclic antidepressants such as amitryptyline (Elavil) and nortryptyline (Pamelor, Aventyl) tolbutamide; zidovudine (Retovir, Trizivir) This is not a complete list of Depakote drug interactions. 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